Do first-in-class cancer drugs receive a pricing premium? – Healthcare Economist





According to an article by Miljković et al. (2023)the answer is ‘No‘. The authors examine cancer treatments with FDA approvals between 2015 and 2020 and identify average Redbook wholesale prices. Drugs were classified into three categories: (i) first approval of a new compound with mechanism of action, (ii) next-in-class approval regardless of tumor type, and (iii) subsequent approval of the same drug. Using this approach, they found that:

There were 224 anticancer drug approvals across 119 individual drugs, with a median annual cost of $196,000 (IQR, $170,000-$277,000). Gene and viral therapies were the most expensive (median, $448,000). [IQR, $448 000-$479 000]), followed by small molecule therapy (median, $244,000 [IQR, $203 000-$321 000), and biologics (median, $185 000 [IQR, $148 000-$195 000]). There was no significant difference in cost between first-in-class, next-in-class, and subsequent approvals of an already approved drug.

The full article is here.



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